No Association Between High-Sensitivity C-Reactive Protein and Carotid Intima-Media Progression: The APAC Study

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• 作者：Anxin Wang ; PhD^* ; ^&dagger ; ; ^&Dagger ; ; ^§ ; ; ^‖ ; Xiaoya Huang ; MD^* ; ^&dagger ; ; ^&Dagger ; ; ^§ ; ; ^¶ ; ; Xiaoxue Liu ; MD^# ; Zhaoping Su ; MS^** ; Jianwei Wu ; MD^* ; ^&dagger ; ; ^&Dagger ; ; ^§ ; ; Shuohua Chen ; MD^&dagger ; &dagger ; ; Xuemei Liu ; MD^&dagger ; &dagger ; ; Chunyu Ruan ; MD^&dagger ; &dagger ; ; Xiuhua Guo ; PhD^‖ ; ^{statguo@ccmu.edu.cn} ; Shouling Wu ; MD^&dagger ; &dagger ; ; ^{drwusl@163.com} ; Xingquan Zhao ; MD ; PhD^* ; ^&dagger ; ; ^&Dagger ; ; ^§ ; ; ^{zxq@vip.163.com}
• 关键词：High-sensitivity C-reactive protein ; carotid intima-media thickness ; atherosclerosis ; inflammation
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：26
• 期：2
• 页码：252-259
• 全文大小：137 K
• 卷排序：26

文摘

High-sensitivity C-reactive protein (hs-CRP) is a risk indicator for atherosclerosis. However, the association between hs-CRP and early carotid atherosclerosis progression is not well established. We undertook a prospective, community-based, observational study to address this question.MethodsCommon carotid artery intima-media thickness (IMT) and hs-CRP values were measured at baseline and after 2 years of follow-up in subjects ≥40 years of age who were participating in the Asymptomatic Polyvascular Abnormalities Community study. Association between hs-CRP values and IMT progression was determined before and after controlling for vascular risk factors.ResultsIMT was measured in a total of 1918 subjects at baseline and 52.97% of those (1016 of 1918) had IMT progression after 2 years. No significant association between progression of IMT over a 2-year period and average hs-CRP levels was found (multivariate-adjusted, P for trend = .280). Both hs-CRP values measured at baseline (P = .836) and after 2 years of follow-up (P = .440) were not associated with IMT progression levels. Average hs-CRP values were not related to IMT progression levels in a dose–response manner (P = .784). In a subgroup analysis stratified by age and sex, hs-CRP values were also not significantly associated with IMT progression levels (P > .05).ConclusionOur results suggest that hs-CRP is not a predictor for the progression of early atherosclerotic changes of the carotid arteries. The hs-CRP levels in early atherosclerosis might be considered as risk markers rather than having a causal role.