Polyketides from the mangrove-derived endophytic fungus Acremonium strictum

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• 作者：Lena Hammerschmidt^a ; Abdessamad Debbab^a ; Tu Duong Ngoc^b ; Victor Wray^c ; Catalina Perè ; z Hemphil^a ; WenHan Lin^d ; Heike Broetz-Oesterhelt^a ; Matthias U. Kassack^e ; Peter Proksch^a ; ^{proksch@uni-duesseldorf.de" class="auth_mail} ; Amal H. Aly^a ; ^{amal.hassan@uni-duesseldorf.de" class="auth_mail}
• 关键词：Acremonium strictum ; Cytotoxic activity ; Endophytic fungus ; Polyketides ; Rhizophora apiculata
• 刊名：Tetrahedron Letters
• 出版年：11 June 2014
• 年：2014
• 卷：55
• 期：24
• 页码：3463-3468
• 全文大小：440 K

文摘

Five new polyketide derivatives, 6′-hydroxypestalotiopsone C (1), acropyrone (2), bicytosporone D (3), waol acid (4), and pestalotiopene C (5), together with seven known metabolites (6–12), were obtained from extracts of the endophytic fungus Acremonium strictum, isolated from the mangrove tree Rhizophora apiculata. The structures of the isolated compounds were elucidated on the basis of comprehensive NMR and MS analysis. Compounds 6, 7, and 9 showed moderate cytotoxic activity against human cisplatin-sensitive (IC₅₀ values 27.1, 76.2, and 8.3 渭M, respectively) and resistant A2780 cell lines (IC₅₀ values 12.6, 30.1, and 19.0 渭M, respectively), whereas only 9 exhibited antibacterial activity against Staphylococcus aureus (MIC value 14.3 渭M).