Investigations on intramolecular 1,3-dipolar cycloadditions for the synthesis of isoxazolo-annulated pyrrolidines, piperidines and azepanes

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• 作者：Martina Wü ; rdemann ; Jens Christoffers ; ^{jens.christoffers@uni-oldenburg.de" class="auth_mail}
• 关键词：1 ; 3-Dipolar cycloaddition ; Nitrogen heterocycles ; Isoxazoles ; Pyrrolidines ; Piperidines ; Azepanes
• 刊名：Tetrahedron
• 出版年：5 August 2014
• 年：2014
• 卷：70
• 期：31
• 页码：4640-4644
• 全文大小：450 K

文摘

Pyrrolidines, piperidines, and azepanes with annulated isoxazole, isoxazoline or isoxazolidine rings were prepared by intramolecular 1,3-dipolar cycloadditions of nitrones or nitrile oxides. The corresponding 1,3-dipoles were obtained from N-Boc-protected and N-allyl-, N-propargyl- or N-(3-butenyl)-substituted 2-aminoethanal or 3-aminopropanal.