Smoking status regulates a novel panel of PIWI-interacting RNAs in head and neck squamous cell carcinoma

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• 作者：Aswini R. Krishnan^a ; ^{arkrishn@ucsd.edu} ; Avinaash Korrapati^a ; ^{akorrapa@ucsd.edu} ; Angela E. Zou^a ; ^{azou@ucsd.edu} ; Yuanhao Qu^a ; ^{yuq024@ucsd.edu} ; Xiao Qi Wang^b ; ^{xqwang@hku.hk} ; Joseph A. Califano^a ; ^{jcalifano@ucsd.edu} ; Jessica Wang-Rodriguez^c ; ^{jessica.wang-rodriguez@va.gov} ; Scott M. Lippman^d ; ^{slippman@ucsd.edu} ; Melbourne F. Hovell^e ; ^{mhovell@cbeachsdsu.org} ; Weg M. Ongkeko^a ; ^{wongkeko@ucsd.edu}
• 关键词：Smoking ; Head and neck neoplasms ; RNA ; Small interfering
• 刊名：Oral Oncology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：65
• 期：Complete
• 页码：68-75
• 全文大小：647 K
• 卷排序：65

文摘

RNA-seq analysis implicated a 13-member piRNA panel in smoking-related HNSCC. 5 piRNAs correlated with clinical variables, including tumor stage and survival. mRNA expression analysis revealed dysregulation of PIWIL1 in smoking-related HNSCC. 6 piRNAs as well as PIWIL1 associated with common genomic alterations in HNSCC.