Performance of the N/TERT epidermal model for skin sensitizer identification via Nrf2-Keap1-ARE pathway activation
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- 作者：Mariam Alloul-Ramdhani ; Cornelis P. Tensen ; Abdoelwaheb El Ghalbzouri ; a.ghalbzouri@lumc.nl" class="auth_mail
- 关键词：N/TERT ; Reconstructed human epidermis ; Skin sensitization ; Keap1 ; Nrf2 ; DNCB
- 刊名：Toxicology in Vitro
- 出版年：August 2014
- 年：2014
- 卷：28
- 期：5
- 页码：982-989
- 全文大小：1182 K
文摘
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Sensitizers activate the Keap1-Nrf2-ARE pathway in primary human keratinocytes and NEMs.
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Implementation of NEMs would overcome the need for human skin tissue.
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OSGIN-1 and GCLM can discriminate DNCB from SDS in keratinocyte based 3D models.
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HMOX-1 is not suitable as a biomarker for sensitization in 3D epidermal models.
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