Nicotine derived genotoxic effects in human primary parotid gland cells as assessed in vitro by comet assay, cytokinesis-block micronucleus test and chromosome aberrations test
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- 作者：Christian Ginzkey ; ginzkey_c@ukw.de" class="auth_mail ; Gudrun Steussloff friehs_g@ukw.de" class="auth_mail ; Christian Koehler koehler_c@ukw.de" class="auth_mail ; Marc Burghartz burghartz_m@ukw.de" class="auth_mail ; Agmal Scherzed scherzed_a@ukw.de" class="auth_mail ; Stephan Hackenberg hackenberg_s@ukw.de" class="auth_mail ; Rudolf Hagen hagen_r@ukw.de" class="auth_mail ; Norbert H. Kleinsasser kleinsasser_n@ukw.de" class="auth_mail
- 关键词：OTM ; Olive tail moment ; CBMN ; cytokinesis-block micronucleus test ; MN ; micronucleus ; CA ; chromosome aberration ; MMS ; methyl-methane-sulfonate
- 刊名：Toxicology in Vitro
- 出版年：August 2014
- 年：2014
- 卷：28
- 期：5
- 页码：838-846
- 全文大小：778 K
文摘
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Genotoxic effects of nicotine between 1 渭M and 1 mM for 1 h were investigated.
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Experiments were performed in vitro in primary cells of human parotid glands.
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Acinar character of cell culture was proven by alpha-amylase expression.
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Increase of DNA migration, micronuclei and chromosome aberrations were determined.
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No cytotoxic effects or an increase of Caspase-3 were measured.
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