Crotoxin from Crotalus durissus terrificus snake venom induces the release of glutamate from cerebrocortical synaptosomes via N and P/Q calcium channels
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- 作者：Rosangela da Silva Lomeoa ; Ana Paula de Faria Gonç ; alvesb ; Carolina Nunes da Silvab ; André ; Tunes de Paulab ; Danielle Oliveira Costa Santosb ; Consuelo Latorre Fortes-Diasc ; Dawidson Assis Gomesb ; Maria Elena de Limaa ; b ; melenalima@icb.ufmg.br" class="auth_mail ; lima.mariaelena@gmail.com" class="auth_mail
- 关键词：Crotoxin ; l-glutamate ; Synaptosomes ; Calcium channels ; PLA2
- 刊名：Toxicon
- 出版年：July 2014
- 年：2014
- 卷：85
- 期：Complete
- 页码：5-16
- 全文大小：1913 K
文摘
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Crotoxin induces l-glutamate release from cerebrocortical synaptosomes.
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l-glutamate release by Crtx depends on its PLA2 activity being inhibited by Sr2+.
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l-glutamate release depends on Ca2+ via N and P/Q calcium channels and internal stock.
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CB, a PLA2, is internalized in neurons, independently of CA and calcium.
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