Bile acids override steatosis in farnesoid X receptor deficient mice in a model of non-alcoholic steatohepatitis
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- 作者：Weibin Wua ; 1 ; Xijun Liua ; 1 ; Xiaomin Penga ; Ruyi Xueb ; Lingling Jia ; Xizhong Shenb ; She Chena ; shechen@fudan.edu.cn" class="auth_mail ; Jianxin Gua ; Si Zhanga ; zhangsi@fudan.edu.cn" class="auth_mail
- 关键词：ACAA1a ; acetyl-CoA acyltransferase 1 ; ACADM ; acyl-coenzyme A dehydrogenase ; ACC1 ; acetyl-CoA carboxylase 1 ; Acox1 ; acyl-CoA oxidase 1 ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; BAs ; bile acids ; BSEP ; bile salt export pump ; CDCA ; chenodeoxycholic acid ; CPT1a ; carnitine palmitoyltransferase 1a ; CYP7A1 ; cholesterol 7伪-hydroxylase ; CYP8B1 ; sterol 12伪-hydroxylase ; DGAT ; diacylglycerol acyltransferases ; FABP1 ; fatty acid binding protein 1 ; FABP4 ; fatty acid binding protein 4 ; FAS
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：23 May 2014
- 年：2014
- 卷：448
- 期：1
- 页码：50-55
- 全文大小：1765 K
文摘
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FXR deficiency enhanced MCD diet-induced hepatic fibrosis.
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FXR deficiency attenuated MCD diet-induced hepatic steatosis.
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FXR deficiency repressed genes involved in fatty acid uptake and triglyceride accumulation.
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