Longitudinal changes in health-related quality of life in preschool children with cerebral palsy of different levels of motor severity

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• 作者：Chih-Jou Lai^a ; ^b ; ^c ; ^{1204milly@gmail.com} ; Chung-Yao Chen^d ; ^e ; ^{jongyau@adm.cgmh.org.tw} ; Chia-Ling Chen^c ; ^f ; ^{clingchen@gmail.com} ; Pei-Ying Sarah Chan^g ; ^h ; ^{chanp@mail.cgu.edu.tw} ; I-Hsuan Shen^f ; ^g ; ^{shenih@mail.cgu.edu.tw} ; Ching-Yi Wu^f ; ^g ; ^{cywu@mail.cgu.edu.tw}
• 关键词：Cerebral palsy ; Quality of life ; Motor severity ; Longitudinal study
• 刊名：Research in Developmental Disabilities
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：61
• 期：Complete
• 页码：11-18
• 全文大小：724 K
• 卷排序：61

文摘

When setting goals for cerebral palsy (CP) interventions, health-related quality of life (HRQoL) is an important outcome.AimsTo compare longitudinal changes in HRQoL in children with CP of different levels of motor severity.Methods and proceduresSeventy-three children with CP were collected and classified into three groups based on Gross Motor Function Classification System (GMFCS) levels. HRQoL was assessed by parent’s proxy of the TNO-AZL Preschool Quality of Life (TAPQOL) at baseline and 6 months later.Outcomes and resultsChildren with GMFCS level V had a lower total TAPQOL score and scores in all domains than those with level I–IV (p < 0.01), except for the non-motor subdomain of physical functioning at follow-up. With regards to longitudinal changes, the children with GMFCS level V had greater improvements in physical (p = 0.016) and cognitive functioning (p = 0.042), but greater deterioration in emotional functioning (p = 0.008) than those with levels I–II at 6 months of follow-up.Conclusions and implicationsMotor severity was associated with TAPQOL scores in all domains and changes in some domains in children with CP. Clinicians should early identify children at risk of a poor HRQoL and plan timely treatment strategies to enhance the HRQoL of children with CP.