Different epigenetic mechanisms of ERα implicated in the fate of fulvestrant-resistant breast cancer

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• 作者：Kouki Tsuboi^a ; Yosuke Kaneko^a ; Takamasa Nagatomo^a ; Rika Fujii^a ; ^b ; Toru Hanamura^a ; ^c ; Tatsuyuki Gohno^a ; Yuri Yamaguchi^d ; Toshifumi Niwa^a ; Shin-ichi Hayashi^a ; ^e ; ^{shin@med.tohoku.ac.jp}
• 关键词：Breast cancer ; Fulvestrant ; Estrogen receptor α ; DNA methylation ; Endocrine therapy resistance
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：115-125
• 全文大小：2185 K
• 卷排序：167

文摘

We evaluated the mechanism of resistance to fulvestrant in MFR and TFR cell lines. High methylation levels upstream of the ERα gene were observed in MFR cells. Following fulvestrant withdrawal, ERα gene expression is not restored in MFR cells. Specific inhibitors in the HER/Src-Akt/MAPK pathway block MFR cell growth. Multiple epigenetic mechanisms regulate ERα gene expression.