Apigenin inhibited hypoxia induced stem cell marker expression in a head and neck squamous cell carcinoma cell line

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• 作者：Yuwaporn Ketkaew^a ; Thanaphum Osathanon^b ; Prasit Pavasant^b ; Sireerat Sooampon^c ; ^{pl_sireerat@yahoo.com}
• 关键词：Apigenin ; Cancer stem cells ; Head and neck squamous cell carcinoma ; Hypoxia
• 刊名：Archives of Oral Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：74
• 期：Complete
• 页码：69-74
• 全文大小：828 K
• 卷排序：74

文摘

Hypoxia increases stemness of cancer stem cells. Apigenin suppresses cancer stem cell marker expression under hypoxia. Apigenin reduces the number of cells expressing stem cell markers under hypoxia. Apigenin might possess the ability to kill cancer stem cells.