TNF-alpha stimulation increases dental pulp stem cell migration in vitro through integrin alpha-6 subunit upregulation

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• 作者：Lei Shi^a ; ^b ; ¹ ; ^{mollyzrx@163.com} ; Shanqi Fu^a ; ¹ ; ^{fushanqi@sina.cn} ; Sidra Fahim^a ; ^{sidra.raf@gmail.com} ; Shuang Pan^a ; ^b ; ^{panshuang79@163.com} ; He Lina^a ; ^{helina426@163.com} ; Xiaodan Mu^a ; ^{1534085074@qq.com} ; Yumei Niu^a ; ^b ; ^{yumeiniu@163.com}
• 关键词：Cytokine ; Migration ; TNF-α ; Integrin α6 ; Dental pulp stem cell ; Regeneration
• 刊名：Archives of Oral Biology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：75
• 期：Complete
• 页码：48-54
• 全文大小：1078 K
• 卷排序：75

文摘

Tumor necrosis factor-α (TNF-a) plays a role in migration of human dental pulp stem cells. TNF-α at a concentration of 50 ng/ml enhances hDPSC migration in vitro. Intgerin α6 expression plays a role in chemotactic migration of TNF-α treated cells. SiRNA treatment for reducing integrin α6 expression in hDPSCs causes a decrease in their migration potential and the cells lose their sense of directionality. Cytoskeletal changes in TNF-α treated group of cells are in line with the migratory phenotype in hDPSCs.