Long-term ethanol self-administration induces ΔFosB in male and female adolescent, but not in adult, Wistar rats

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• 作者：Aranza Wille-Bille^a ; Soledad de Olmos^a ; Leonardo Marengo^a ; ^b ; Florencia Chiner^a ; ^b ; Ricardo Marcos Pautassi^a ; ^b ; ^{rpautassi@gmail.com}
• 关键词：Adolescent ; Adult ; Ethanol drinking ; Ethanol-induced locomotor activity ; ΔFosB
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2017
• 出版时间：6 March 2017
• 年：2017
• 卷：74
• 期：Complete
• 页码：15-30
• 全文大小：3454 K
• 卷排序：74

文摘

Adolescent, but not adult, rats exhibited escalation of ethanol intake. Ethanol intake induced ΔFosB, particularly at AcbC, AcbSh, BLA and DMS. Adolescents exhibited greater ΔFosB induction, compared to adults, at most areas. Females exhibited greater ΔFosB induction, compared to males, at most areas. Adolescents and adults exhibited similar ethanol-induced stimulation and anxiety.