Nontraumatic Convexal Subarachnoid Hemorrhage Concomitant with Acute Ischemic Stroke

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• 作者：Makoto Nakajima ; MD ; PhD^&lowast ; ; ^{nakazima@fc.kuh.kumamoto-u.ac.jp" class="auth_mail} ; Yuichiro Inatomi ; MD ; PhD^&lowast ; ; Toshiro Yonehara ; MD ; PhD^&lowast ; ; Teruyuki Hirano ; MD ; PhD^&dagger ; ; Yukio Ando ; MD ; PhD^&Dagger ;
• 关键词：Carotid stenosis ; cerebral amyloid angiopathy ; convexal subarachnoid hemorrhage ; intracranial stenosis ; superficial siderosis
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：July 2014
• 年：2014
• 卷：23
• 期：6
• 页码：1564-1570
• 全文大小：1057 K

文摘

Nontraumatic convexal subarachnoid hemorrhage (cSAH) rarely occurs subsequent to acute ischemic stroke. The incidence, clinical background characteristics, and outcomes in acute ischemic stroke patients with cSAH were investigated.

Methods

Our stroke center database was reviewed to identify patients with acute ischemic stroke/transient ischemic attack (TIA) who demonstrated acute cSAH within 14 days of admission between 2005 and 2011. Background characteristics, clinical course, and outcomes at discharge and 3 months after onset were investigated in these patients.

Results

Of 4953 acute stroke/TIA patients, cSAH was observed in 8 (.14%) patients (7 men, mean age 71 years): 7 were detected incidentally, and the other was found immediately after a convulsion. Two patients died during their hospital stay, 1 died after discharge, and 3 were dependent at 3 months. Major artery occlusion or severe stenosis was observed in 5 patients. Two patients subsequently developed subcortical hemorrhage. On gradient echo imaging, lobar cerebral microbleeds were observed in 2 patients, and chronic superficial siderosis was observed in 2 patients.

Conclusions

In this retrospective review of cases with ischemic stroke and cSAH, over half of patients had occlusion of major arteries. Cerebral amyloid angiopathy was suggested by magnetic resonance imaging findings and subsequent events in 3 patients. The overall outcome was unfavorable although the causal relationship with cSAH was unclear.