p300 cooperates with c-Jun and PARP-1 at the p300 binding site to activate RhoB transcription in NSC126188-mediated apoptosis
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- 作者：Bo-Kyung Kima ; Joo-Young Ima ; Gyoonhee Hanb ; Woo-Jung Leea ; Kyoung-Jae Wona ; c ; Kyung-Sook Chunga ; Kyeong Leed ; Hyun Seung Bana ; KyungBin Songe ; Misun Wona ; c ; misun@kribb.re.kr" class="auth_mail
- 关键词：RhoB ; ras homolog gene family member B ; FTIs ; farnesyltransferase inhibitors ; SAPK/JNK ; stress-activated protein kinase/c-Jun N-terminal kinase ; MAPK ; mitogen-activated protein kinase ; HDAC ; histone deacetylase ; HAT ; histone acetylase ; PARP-1 ; poly(ADP-ribose) polymerase-1
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：May 2014
- 年：2014
- 卷：1839
- 期：5
- 页码：364-373
- 全文大小：1684 K
文摘
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We provide evidences that the p300 binding site plays a role in RhoB transcription.
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p300 cooperates with c-Jun and PARP-1 at the p300 binding site of the RhoB promoter.
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We showed pro-apoptotic functions of p300 and PARP-1 in RhoB-mediated apoptosis.
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35">The mechanism underlying NSC126188 regulation of RhoB differs from that of FTI-77.
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