TLR3 signaling is downregulated by a MAVS isoform in epithelial cells

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• 作者：Omar Lakhdari^a ; ^b ; ^{olakhdari@ucsd.edu} ; Christopher S. McAllister^a ; ^b ; Michael Wang^a ; ^b ; Ivelina Minev^a ; ^b ; Lawrence S. Prince^c ; Lars Eckmann^b ; Martin F. Kagnoff^a ; ^b ; ^c
• 关键词：TLR3 ; MAVS ; Isoform ; Interferon beta ; Regulation ; Epithelial cells ; miniMAVS ; HCT116
• 刊名：Cellular Immunology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：310
• 期：Complete
• 页码：205-210
• 全文大小：686 K
• 卷排序：310

文摘

Extracellular poly(I:C) activates TLR3-dependent IFN-β expression in HCT116. MAVS silencing upregulates IFN-β production via upregulation of NF-κB and IRF3 signaling. TLR3 signaling is regulated by miniMAVS, a 50 kDa isoform of MAVS.