Hepatic expansion of virus-specific CD8⁺BTLA⁺ T cells with regulatory properties in chronic hepatitis B virus infection

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• 作者：Huaizhou Wang^a ; ^b ; Beiying Wu^a ; Lei Li^c ; Liang Hu^a ; Jiafei Lin^a ; Cen Jiang^a ; Gang Cai^a ; ^{caigangsmmu@hotmail.com} ; Qian Shen^b
• 关键词：ALT ; alanine aminotransferase ; BTLA ; B and T lymphocyte attenuator ; CHB ; chronic hepatitis B ; CM ; central memory ; CMV ; cytomegalovirus ; CTL ; cytotoxic T lymphocyte ; DC ; dendritic cell ; EM ; effector memory ; HIV ; human immunodeficiency virus ; HBV ; hepatitis B virus ; HBcAg ; hepatitis B virus core antigen ; HBsAg ; hepatitis B virus surface antigen ; HCV ; hepatitis C virus ; IFN- ; interferon- ; IL-2 ; interleukin-2 ; LIL ; liver infiltrated lymphocyte ; PBMC ; peripheral blood monouclear cell ; PD-1 ; programme
• 刊名：Cellular Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：311
• 期：Complete
• 页码：36-45
• 全文大小：2619 K
• 卷排序：311

文摘

BTLA were expressed highly on intrahepatic HBV-specific T cells from patients with chronic HBV infection. BTLA+ HBV-specific T cells play regulatory role. BTLA signaling-mediated IL-10 secretion plays a key role in suppression.