Comparison between semiquantitative and quantitative methods for the assessment of knee synovitis in osteoarthritis using non-enhanced and gadolinium-enhanced MRI

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• 作者：M.D. Crema^&dagger ; ; ^&Dagger ; ; ^{michelcrema@gmail.com} ; F.W. Roemer^&dagger ; ; ^‖ ; L. Li^¶ ; ; R.C. Alexander^# ; ^a ; I.P. Chessell^&dagger ; &dagger ; ; A.D. Dudley^&dagger ; &dagger ; ; R. Karlsten^&Dagger ; &Dagger ; ; ^a ; L.B. Rosen^§ ; § ; ; ^a ; A. Guermazi^&dagger ;
• 关键词：Osteoarthritis ; Knee ; Synovitis ; Magnetic resonance imaging
• 刊名：Osteoarthritis and Cartilage
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：267-271
• 全文大小：542 K
• 卷排序：25

文摘

To compare different semiquantitative and quantitative methods using both non-enhanced and gadolinium-enhanced MRI techniques for the assessment of synovitis in knee osteoarthritis (OA).MethodsKnees with end-stage clinical OA in patients undergoing total knee replacement surgery were included in this cross-sectional study. MRI was performed on all knees. Standard non-enhanced and gadolinium-enhanced sequences were acquired. Using non-enhanced MRI, we semiquantitatively assessed two features widely used as surrogates for synovitis: effusion-synovitis and Hoffa-synovitis. Using gadolinium-enhanced sequences, we semiquantitatively assessed synovial thickness. We quantitatively evaluated the total synovial volume on the gadolinium-enhanced sequences as well. We assessed the correlations of effusion-synovitis and Hoffa-synovitis with synovial thickness and volume, applying Spearman correlation analysis. The diagnostic performance of both synovitis features on non-enhanced MRI was assessed using synovial thickness on gadolinium-enhanced MRI as the reference.ResultsA total of 104 subjects (one knee per subject) were included. Correlations of effusion-synovitis with synovial thickness and volume were r = 0.41 and r = 0.43 (P < .001) r = 0.32 and r = 0.39 (P < .0001).ConclusionUsing synovial thickness assessed on gadolinium-enhanced sequences as the reference, effusion-synovitis showed superior correlations and sensitivity. Effusion-synovitis should be preferred over Hoffa-synovitis as a surrogate marker for synovial thickening, in studies of knee OA for which gadolinium-enhanced sequences are not available.