Toxicities and dose-volume histogram parameters of MRI-based brachytherapy for cervical cancer

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• 作者：Youngkyong Kim¹ ; Yeon-Joo Kim¹ ; ² ; ^{jane2000md@gmail.com} ; Joo-Young Kim¹ ; ² ; Young Kyung Lim¹ ; Chiyoung Jeong¹ ; ³ ; Jonghwi Jeong¹ ; Meyoung Kim¹ ; ⁴ ; Myong Cheol Lim² ; Sang-Soo Seo² ; Sang-Yoon Park²
• 关键词：Toxicity ; Cervical neoplasms ; DVH parameters ; Magnetic resonance imaging ; Brachytherapy
• 刊名：Brachytherapy
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：16
• 期：1
• 页码：116-125
• 全文大小：1574 K
• 卷排序：16

文摘

To analyze the toxicities and dose–volume histogram parameters of external-beam and magnetic resonance imaging–based intracavitary brachytherapy in cervical cancer patients.Methods and MaterialsAcute and late toxicities were assessed in 135 patients divided into four groups: group 1, grade 0; group 2, grades 1–4; group 3, grades 0–1; and group 4, grades 2–4. The doses at the International Commission on Radiation Units and Measurements (DICRU) and minimum doses to the most exposed 0.1, 1, 2, and 5 cc (D0.1cc, D1cc, D2cc, and D5cc) of normal organs were calculated as equivalent doses in 2 Gy (α/β = 3).ResultsThe median follow-up was 35.2 months. For rectum, DICRU, D0.1cc, D1cc, and D2cc were significantly different between groups 1 and 2 and DICRU, D0.1cc, and D1cc between groups 3 and 4. For bladder, D0.1cc, D1cc, and D2cc were significantly different between groups 1 and 2 and DICRU, D1cc, D2cc, and D5cc between groups 3 and 4. Grade 2–4 bladder toxicity occurred in fewer patients with D2cc ≤ 95 Gy than those with D2cc > 95 Gy (7% vs. 22%, p = 0.014).ConclusionsDICRU, D0.1cc, D1cc, and D2cc are relevant for predicting late rectal toxicities. The patients with bladder D2cc > 95 Gy are required to be in close observation for severe late toxicities.