Acetaminophen-induced hepatotoxicity: Preventive effect of trans anethole

详细信息    查看全文

• 作者：Bruno Ambró ; sio da Rocha^a ; ^{brunoambrosiorocha@gmail.com} ; Alessandra M. Versuti Ritter^b ; ^{ale_mileni@hotmail.com} ; Franciele Queiroz Ames^a ; ^{francieleames@gmail.com} ; Odinei Hess Gonç ; alves^c ; ^{odinei@utfpr.edu.br} ; Fernanda Vitó ; ria Leimann^c ; ^{fernanda@utfpr.edu.br} ; Lí ; via Bracht^d ; ^{liviabracht@gmail.com} ; Maria Raquel Març ; al Natali^e ; ^{mrmnatali@uem.br} ; Roberto Kenji Nakamura Cuman^a ; Ciomar Ap. Bersani-Amado^a ; ^{cabamado@uem.br}
• 关键词：Trans anethole ; Acetaminophen ; Hepatoprotection
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：86
• 期：Complete
• 页码：213-220
• 全文大小：3089 K
• 卷排序：86

文摘

The hepatotoxicity induced by APAP is caused by the excessive production of N-acetyl-para-benzoquinone imine (NAPQI), which, when reacting with hepatic proteins proved to cause irreversible lesions. Associated with this process, an intense inflammatory process is also evidenced, characterized by the increased cell influx and production/release of inflammatory mediators. Trans anethole, an aromatic compounds has been showed anti-inflammatory efficacy by inhibit the cellular recruitment and synthesis/releases of many proinflammatory mediators such as prostaglandin (PGE2), cytokines (TNF, IL-1) and nitrico oxide (NO). The aim of this study is to investigate the effect of trans anethole on some inflammatory parameters that are involved in hepatotoxicity induced by high doses of acetaminophen. Our results demonstrate that treatment with AN at doses 125 and 250 mg/kg once a day for seven days prevented the changes caused by the APAP overdose, showing less intensity in the histological changes (necrosis, size of hepatocyte area and inflammatory infiltration), and corroborating the findings of serum activities of transaminases and phosphatases and the activity of the enzyme myeloperoxidase. In addition, the treatment prevented the up-regulation of proinflammatory mediators such as NO, TNF, IL-1α, MIP-1α and MCP-1 and induced the up-regulation of anti-inflammatory cytokines (IL-4 and IL-10). Thus, our results demonstrate a possible protective effect of trans anethole on the hepatotoxicity induced by APAP.