The increased number of tumor-associated macrophage is associated with overexpression of VEGF-C, plays an important role in Kazakh ESCC invasion and metastasis

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• 作者：Jian Ming Hu^a ; ^c ; Kai Liu^c ; Ji Hong Liu^c ; Xian Li Jiang^c ; Xue Li Wang^c ; Lan Yang^c ; Yun Zhao Chen^c ; Chun Xia Liu^c ; Shu Gang Li^d ; Xiao Bin Cui^c ; Hong Zou^c ; Li Juan Pang^c ; Jin Zhao^c ; Yan Qi^c ; Wei Hua Liang^c ; Xiang Lin Yuan^a ; Feng Li^a ; ^b ; ^c ; ^{Lifeng7855@126.com}
• 关键词：Tumor associated macrophages ; CD163 ; VEGF ; Esophageal squamous cell carcinoma ; Kazakh
• 刊名：Experimental and Molecular Pathology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：102
• 期：1
• 页码：15-21
• 全文大小：1507 K
• 卷排序：102

文摘

Tumor associated macrophages (TAMs) play an important role in the growth, progression, and metastasis of tumors. The distribution of TAMs in Kazakh esophageal squamous cell carcinoma (ESCC) is not determined. We aimed to investigate the role of TAMs in the occurrence and progression of Kazakh ESCC. CD163 was used as the TAM marker, and immunohistochemistry (IHC) counts were used to quantify the density of TAMs in tumor nest and surrounding stroma. IHC staining was used to evaluate the expression of vascular endothelial growth factor C (VEGF-C) in Kazakh ESCC and cancer adjacent normal (CAN) tissues. The density of TAMs in Kazakh ESCCs tumor nest and stromal was significantly higher than that in CAN tissues. The increased number of CD163-positive TAMs in tumor nest and tumor stromal was positively associated with Kazakh ESCC lymph node metastasis and clinical stage progression. Meanwhile, the expression of VEGF-C in Kazakh ESCCs was significantly higher than that in CAN tissues. Overexpression of VEGF-C in Kazakh ESCCs was significantly associated with gender, depth of tumor invasion, lymph node metastasis and tumor clinical stage. The increased number of TAMs, either in the tumor nests or tumor stroma was positively correlated with the overexpression of VEGF-C, which may promote lymphangiogenesis and play an important role in the invasion and metastasis of Kazakh ESCC.