Tyrosine kinase receptor c-ros-oncogene 1 mediates TWIST-1 regulation of human mesenchymal stem cell lineage commitment

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• 作者：Esther Camp^a ; ^b ; Peter J. Anderson^c ; Andrew C.W. Zannettino^b ; ^d ; Stan Gronthos^a ; ^b ; ^{stan.gronthos@adelaide.edu.au}
• 关键词：Mesenchymal stem cells ; Bone marrow stromal cells ; TWIST-1 ; C-ROS-1 ; PI3K/AKT/mTOR signalling
• 刊名：Bone
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：94
• 期：Complete
• 页码：98-107
• 全文大小：1522 K
• 卷排序：94

文摘

Tyrosine kinase receptor c-ros-oncogene 1 (C-ROS-1) is identified as a novel downstream Twist-1 target in human BMSC. Twist-1 negatively regulates expression of C-ROS-1 in BMSC. Knock-down of c-ros-1 results in reduced osteogenic potential, increased adipogenic potential and an increase in PI3K/AKT/mTORC1 signalling. c-ros-1 and PI3K/AKT/mTORC1 signalling are novel, Twist-1 downstream mechanisms, involved in BMSC fate switching between osteogenesis and adipogenesis.