ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis

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• 作者：Srinivas Vinod Saladi¹ ; ⁵ ; Kenneth Ross¹ ; Mihriban Karaayvaz¹ ; ⁵ ; Purushothama R. Tata² ; ⁴ ; ⁵ ; ⁷ ; Hongmei Mou² ; ⁴ ; ⁵ ; Jayaraj Rajagopal² ; ³ ; ⁴ ; ⁵ ; Sridhar Ramaswamy¹ ; ⁵ ; ⁶ ; Leif W. Ellisen¹ ; ⁵ ; ⁸ ; ^{lellisen@mgh.harvard.edu}
• 关键词：squamous cell carcinoma ; p63 ; SWI/SNF (BAF) complex ; chromatin remodeling ; hippo pathway ; HNSCC ; ACTL6A ; YAP1
• 刊名：Cancer Cell
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：35-49
• 全文大小：4842 K
• 卷排序：31

文摘

ACTL6A is co-amplified, co-expressed, and physically associated with p63 in HNSCC ACTL6A/p63-mediated transcription drives undifferentiated regenerative proliferation An ACTL6A/p63 complex suppresses WWC1 to activate YAP and promote tumorigenesis ACTL6A and an activated YAP pathway confer poor prognosis in primary HNSCC