ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis
文摘
ACTL6A is co-amplified, co-expressed, and physically associated with p63 in HNSCC ACTL6A/p63-mediated transcription drives undifferentiated regenerative proliferation An ACTL6A/p63 complex suppresses WWC1 to activate YAP and promote tumorigenesis ACTL6A and an activated YAP pathway confer poor prognosis in primary HNSCC