Alpha-foetoprotein (AFP): A multi-purpose marker in hepatocellular carcinoma

详细信息    查看全文

• 作者：Chloé ; Sauzay^a ; ^b ; Alexandra Petit^a ; Anne-Marie Bourgeois^a ; Jean-Claude Barbare^c ; Bruno Chauffert^d ; Antoine Galmiche^a ; ^b ; ^{Galmiche.Antoine@chu-amiens.fr} ; Aline Houessinon^a ; ^b
• 关键词：AFP ; alpha-foetoprotein ; C/EBP ; CCAAT/enhancer binding protein ; CTC ; circulating tumour cells ; eIF-2α ; eukaryotic translation initiation factor-2α ; HCC ; hepatocellular carcinoma ; HNF ; Hepatocyte Nuclear Factor ; IRE-1α ; Inositol-Requiring Enzyme-1α ; miRNA ; microRNA ; PERK ; PKR-like Endoplasmic Reticulum Kinase ; PIVKA-II ; protein induced by vitamin K absence-II ; RIDD ; Regulated IRE-1α-Dependent Decay ; UPR ; Unfolded Protein Response
• 刊名：Clinica Chimica Acta
• 出版年：2016
• 出版时间：1 December 2016
• 年：2016
• 卷：463
• 期：Complete
• 页码：39-44
• 全文大小：481 K
• 卷排序：463

文摘

AFP status defines a subset of HCC with particular biological properties. AFP may play an active role in hepatocarcinogenesis. The Unfolded Protein Response (UPR) regulates AFP production. Serum levels of AFP might reflect tumour proteostasis in the therapeutic context.