Saponins from the roots of Platycodon grandiflorum ameliorate high fat diet-induced non-alcoholic steatohepatitis

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• 作者：Jae Ho Choi^a ; ¹ ; Sun Woo Jin^a ; ¹ ; Chul Yung Choi^b ; ¹ ; Hyung Gyun Kim^a ; Se Jong Kim^a ; Hyun Sun Lee^c ; Young Chul Chung^d ; Eun Ju Kim^e ; Young Chun Lee^e ; Hye Gwang Jeong^a ; ^{hgjeong@cnu.ac.kr}
• 关键词：ACOX ; acyl-CoA oxidase ; ARE ; antioxidant response element ; CKS ; Platycodon grandiflorum root-derived saponins ; CPT-1 ; carnitine palmitoyltransferase-1 ; HFD ; High fat diet ; HSCs ; hepatic stellate cells ; NAFLD ; non-alcoholic fatty liver disease ; NASH ; non-alcoholic steatohepatitis ; NF-κB ; nuclear factor-kappaB ; Nrf2 ; nuclear erythroid 2-related factor 2 ; PPARα ; peroxisomal proliferator-activated receptor alpha
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：86
• 期：Complete
• 页码：205-212
• 全文大小：2227 K
• 卷排序：86

文摘

CKS ameliorates HFD-induced hepatic fibrosis. CKS inhibits HFD-induced pro-inflammatory cytokines and fibrotic markers. The effect relies on the activation of antioxidant enzyme and fatty acid oxidation.