Relationship between HHV8 infection markers and insulin sensitivity in ketosis-prone diabetes

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• 作者：J.-L. Nguewa^a ; ^b ; ^{nguewa.jeanlouis@yahoo.fr} ; E. Lontchi-Yimagou^c ; F. Agbelika^d ; M. AitDjoudi^a ; P. Boudou^e ; S. Choukem^f ; ^g ; E. Sobngwi^c ; ^h ; J.-F. Gautier^a ; ^b ; ⁱ
• 关键词：Human herpesvirus 8 ; Insulin resistance ; Ketosis-prone type 2 diabetes ; Type 2 diabetes
• 刊名：Diabetes & Metabolism
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：43
• 期：1
• 页码：79-82
• 全文大小：462 K
• 卷排序：43

文摘

Peripheral tissue resistance to insulin action is a characteristic of type 2 diabetes mellitus (T2DM). It has also been reported that some chronic viral infections can contribute to insulin resistance. Human herpesvirus (HHV)-8 infection has been detected in T2DM patients in previous studies. Our study investigated whether the presence of the virus is associated with insulin resistance in patients with ketosis-prone type 2 diabetes (KPD), as reported with other viruses.Research design and methodsA total of 11 insulin-free KPD patients positive (+) and seven patients who were negative (−) for HHV-8 infection were recruited; the latter had KPD that was well controlled (HbA1c = 6.2 ± 0.7%). A two-step euglycaemic–hyperinsulinaemic clamp test coupled with deuterated [6,6-2H2]glucose was used to assess insulin sensitivity, non-esterified fatty acid (NEFA) suppression and endogenous glucose production.ResultsIn KPD patients, whether HHV-8+ or HHV-8−, there were no differences in NEFA release, endogenous glucose production or insulin sensitivity (M value).ConclusionAsymptomatic HHV-8 infection does not appear to be associated with decreased insulin sensitivity in diabetic patients. These results should now be confirmed in a larger sample population.