Proteomic analysis reveals aberrant expression of CALR and HSPA5 in thyroid tissues of Graves' disease

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• 作者：Shuai Meng¹ ; Wen Zhang¹ ; Li-juan Guan ; Fatuma-said Muhali ; Jiao-zhen Zhou ; Rong-hua Song ; Jian Xu ; Jin-an Zhang ; ^{zhangjinan@hotmail.com}
• 关键词：Graves' disease(GD) ; Proteomics ; Calreticulin(CALR) ; Heat shock 70  ; kDa protein 5(HSPA5) ; Endoplasmic reticulum (ER) stress
• 刊名：Clinical Biochemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：50
• 期：1-2
• 页码：40-45
• 全文大小：1171 K
• 卷排序：50

文摘

CALR and HSPA5 are overexpressed in GD. ER-stress may be involved in the pathogenesis of GD. 2-DE combined with MALDI-TOF-MS may be a useful way to find new protein biomarkers.