Cooperative Binding of Transcription Factors Orchestrates Reprogramming

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• 作者：Constantinos Chronis¹ ; ² ; ³ ; Petko Fiziev¹ ; ² ; ³ ; Bernadett Papp¹ ; ² ; Stefan Butz¹ ; ² ; Giancarlo Bonora¹ ; ² ; Shan Sabri¹ ; ² ; Jason Ernst¹ ; ² ; ^{jason.ernst@ucla.edu} ; Kathrin Plath¹ ; ² ; ⁴ ; ^{kplath@mednet.ucla.edu}
• 关键词：reprogramming ; pluripotency ; induced pluripotent stem cells ; enhancers ; transcription factors ; Oct4 ; Klf4 ; Sox2 ; collaborative binding
• 刊名：Cell
• 出版年：2017
• 出版时间：26 January 2017
• 年：2017
• 卷：168
• 期：3
• 页码：442-459.e20
• 全文大小：14516 K
• 卷排序：168

文摘

Genome-wide annotation of cis-regulatory elements at four reprogramming stages Somatic enhancer silencing is initiated through several OSK-induced mechanisms Stepwise pluripotency enhancer selection is dependent on collaborative TF binding Stage-specific TFs influence OSK occupancy and enhancer selection