Usefulness of Iron Deficiency Correction in Management of Patients With Heart Failure [from the Registry Analysis of Iron Deficiency-Heart Failure (RAID-HF) Registry]

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• 作者：Harm Wienbergen ; MD^a ; ^{harm.wienbergen@klinikum-bremen-ldw.de} ; Otmar Pfister ; MD^b ; Matthias Hochadel ; PhD^c ; Stephan Michel^a ; Oliver Bruder ; MD^d ; Bjö ; rn Andrew Remppis ; MD^e ; Micha Tobias Maeder ; MD^f ; Ruth Strasser ; MD^g ; Wolfgang von Scheidt ; MD^h ; Matthias Pauschinger ; MDⁱ ; Jochen Senges ; MD^c ; Rainer Hambrecht ; MD^a ; for the RAID-HF (Registry Analysis of Iron Deficiency&ndash ; Heart Failure) REGISTRY Study Group
• 刊名：The American Journal of Cardiology
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：118
• 期：12
• 页码：1875-1880
• 全文大小：352 K
• 卷排序：118

文摘

Iron deficiency (ID) has been identified as an important co-morbidity in patients with heart failure (HF). Intravenous iron therapy reduced symptoms and rehospitalizations of iron-deficient patients with HF in randomized trials. The present multicenter study investigated the “real-world” management of iron status in patients with HF. Consecutive patients with HF and ejection fraction ≤40% were recruited and analyzed from December 2010 to October 2015 by 11 centers in Germany and Switzerland. Of 1,484 patients with HF, iron status was determined in only 923 patients (62.2%), despite participation of the centers in a registry focusing on ID and despite guideline recommendation to determine iron status. In patients with determined iron status, a prevalence of 54.7% (505 patients) for ID was observed. Iron therapy was performed in only 8.5% of the iron-deficient patients with HF; 2.6% were treated with intravenous iron therapy. The patients with iron therapy were characterized by a high rate of symptomatic HF and anemia. In conclusion, despite strong evidence of beneficial effects of iron therapy on symptoms and rehospitalizations, diagnostic and therapeutic efforts on ID in HF are low in the actual clinical practice, and the awareness to diagnose and treat ID in HF should be strongly enforced.