IFCC approved HPLC reference measurement procedure for the alcohol consumption biomarker carbohydrate-deficient transferrin (CDT): Its validation and use

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• 作者：Franç ; ois Schellenberg^a ; Jos Wielders^b ; ¹ ; ^{joswielders@gmail.com} ; Raymond Anton^c ; Vincenza Bianchi^d ; Jean Deenmamode^e ; Cas Weykamp^f ; John Whitfield^g ; Jan-Olof Jeppsson^h ; Anders Helanderⁱ
• 关键词：CDT ; Disialotransferrin ; HPLC ; Alcohol biomarker ; Standardization ; Reference Measurement Procedure (RMP)
• 刊名：Clinica Chimica Acta
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：465
• 期：Complete
• 页码：91-100
• 全文大小：783 K
• 卷排序：465

文摘

Carbohydrate-deficient transferrin (CDT) is a serum transferrin glycoform profile seen in sustained high alcohol consumption CDT has become an important clinical and forensic biomarker for detection and follow-up of chronic high alcohol use A CDT reference measurement procedure (RMP) has been missing and field methods differ in results and reference intervals To end this confusion, the IFCC founded a Working Group for standardization of CDT measurement (WG-CDT) The WG-CDT defined the CDT measurand and selected an anion-exchange HPLC measurement procedure as candidate RMP (cRMP) The WG-CDT has validated the cRMP according to ISO 15193 and established the measurement uncertainty and reference interval Following IFCC approval of the validated cRMP and its description of use, the method will be known as the IFCC-RMP for CDT