Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation

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• 作者：Fei Wu^a ; ^b ; Xiangpeng Dai^b ; Wenjian Gan^b ; Lixin Wan^b ; ^c ; Min Li^d ; ^e ; Nicholas Mitsiades^d ; ^e ; Wenyi Wei^b ; Qiang Ding^a ; ^{dr_dingqiang@hotmail.com} ; Jinfang Zhang^b ; ^{jzhang17@bidmc.harvard.edu}
• 关键词：Cdc20 ; SPOP ; Degradation ; Ubiquitination ; Cancer
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：385
• 期：Complete
• 页码：207-214
• 全文大小：2037 K
• 卷排序：385

文摘

Cullin 3 negatively regulates Cdc20 stability in prostate cancer. SPOP promotes Cdc20 poly-ubiquitination and degradation. Prostate cancer-associated mutants are defective in interaction with Cdc20. SPOP-deficient prostate cancer cells become resistant to Cdc20 inhibitor.