Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling

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• 作者：Yoku Hayakawa¹ ; ² ; ¹² ; Kosuke Sakitani¹ ; ¹² ; Mitsuru Konishi² ; Samuel Asfaha¹ ; ³ ; Ryota Niikura² ; Hiroyuki Tomita⁴ ; Bernhard W. Renz¹ ; ⁵ ; Yagnesh Tailor¹ ; Marina Macchini¹ ; Moritz Middelhoff¹ ; Zhengyu Jiang¹ ; Takayuki Tanaka¹ ; Zinaida A. Dubeykovskaya¹ ; Woosook Kim¹ ; Xiaowei Chen¹ ; Aleksandra M. Urbanska¹ ; Karan Nagar¹ ; Christoph B. Westphalen¹ ; ⁶ ; Michael Quante⁷ ; Chyuan-Sheng Lin⁸ ; ⁹ ; Michael D. Gershon⁸ ; Akira Hara⁴ ; Chun-Mei Zhao¹⁰ ; Duan Chen¹⁰ ; Daniel L. Worthley¹ ; ¹¹ ; Kazuhiko Koike² ; Timothy C. Wang¹ ; ¹³ ; ^{tcw21@columbia.edu}
• 关键词：NGF ; gastric cancer ; acetylcholine ; Lgr5 ; wnt ; YAP ; Dclk1 ; tuft cell ; stem cell ; muscarinic acetylcholine receptor type 3
• 刊名：Cancer Cell
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：31
• 期：1
• 页码：21-34
• 全文大小：6800 K
• 卷排序：31

文摘

NGF expression is induced in gastric cancer by ACh from nerves and tuft cells NGF promotes innervation and proliferation in gastric epithelium Blockade of NGF or ablation of cholinergic tuft cells inhibits tumor development Cholinergic signaling activates YAP signaling that is essential for Wnt activation