P2X7Rs are involved in cell death, growth and cellular signaling in primary human osteoblasts

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• 作者：Ankita Agrawal^a ; Zanne Henriksen^a ; Susanne Syberg^a ; Solveig Petersen^a ; Derya Aslan^a ; Marie Solgaard^a ; Nis Nissen^b ; Tommy Korsgaard Larsen^c ; Peter Schwarz^d ; ^e ; Thomas H. Steinberg^f ; Niklas Rye Jø ; rgensen^a ; ^g ; ^{niklas@dadlnet.dk}
• 关键词：Calcium signaling ; P2X7R ; Osteoblast
• 刊名：Bone
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：95
• 期：Complete
• 页码：91-101
• 全文大小：2068 K
• 卷排序：95

文摘

Cells derived from human trabecular explants express a functional P2X7R. These primary osteoblasts have a positive alkaline phosphatase activity. They are fully differentiated with the ability to form mineralized nodules. P2X7R mediates transcriptional regulation of osteoblastic markers. P2X7R is involved in propagation of mechanically-induced intercellular signaling.