Increased expression of markers of early atherosclerosis in patients with inflammatory bowel disease

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• 作者：Maria Cappello^a ; ¹ ; ^{marica.cappello61@gmail.com} ; Anna Licata^a ; ¹ ; Vincenza Calvaruso^a ; Ivana Bravat&agrave ; ^a ; Alessandra Aiello^a ; Daniele Torres^b ; Vittoriano Della Corte^b ; Antonino Tuttolomondo^b ; Maria Perticone^c ; Giuseppe Licata^b ; Antonio Craxì ; ^a ; Calogero Camm&agrave ; ^a
• 关键词：IBD ; Inflammatory bowel disease ; CD ; Crohn's Disease ; UC ; Ulcerative Colitis ; IMT ; Intima media thickness ; PWV ; Pulse wave velocity ; AIx ; Augmentation index ; DBP ; Diastolic blood pressure ; SBP ; Systolic blood pressure ; FMD ; Flow mediated dilation ; ESR ; Erythrocyte-sedimentation rate ; CRP ; C-reactive protein
• 刊名：European Journal of Internal Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：37
• 期：Complete
• 页码：83-89
• 全文大小：336 K
• 卷排序：37

文摘

This study investigated expression of markers of subclinical atherosclerosis (ATS) in IBD. Both IMT and arterial stiffness parameters (PWV and AIx) are increased in IBD patients. Markers of ATS are significantly increased in patients on 5-ASA therapy only. Therapies able to obtain a full control of inflammation may reverse also ATS risk in IBD. Longitudinal studies are needed to confirm the correlation between ATS markers, inflammation and drug options in IBD.