MicroRNAs as novel targets and tools in cancer therapy

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• 作者：Mohammed L. Abba^a ; ¹ ; Nitin Patil^a ; ¹ ; Jö ; rg H. Leupold^a ; ¹ ; Marcin Moniuszko^b ; Jochen Utikal^c ; ^d ; Jacek Niklinski^e ; Heike Allgayer^a ; ^{heike.allgayer@medma.uni-heidelberg.de}
• 关键词：microRNAs ; Cancer ; Therapy ; Stem cells ; Metastasis
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 February 2017
• 年：2017
• 卷：387
• 期：Complete
• 页码：84-94
• 全文大小：1803 K
• 卷排序：387

文摘

MicroRNAs are both relevant molecular targets and therapeutic targets in cancer. Diverse synthetic antagonists have been developed and can be used to target miRNAs in vivo. The delivery of miRNA mimics and inhibitors to specific organs is still a therapeutic challenge. A liposome-based miR-34 mimic is the first cancer-targeted microRNA drug to enter phase I clinical trials in human patients.