Comparison between perfusion computed tomography and dynamic contrast-enhanced magnetic resonance imaging in assessing glioblastoma microvasculature

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• 作者：Zhong Zheng Jia^a ; ^{jzz2397@163.com} ; Wei Shi^b ; ^{sw740104@hotmail.com} ; Jin Long Shi^b ; ^{shij_ns@163.com} ; Dan Dan Shen^a ; ^{1021121084@qq.com} ; Hong Mei Gu^a ; ^{guhongmei71@163.com} ; Xue Jun Zhou^a ; ^{56516400@qq.com} ; ^{seesealimin@163.com}
• 关键词：Glioblastoma ; Magnetic resonance imaging ; Computed tomography ; Dynamic contrast-enhanced ; Perfusion ; Comparison
• 刊名：European Journal of Radiology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：87
• 期：Complete
• 页码：120-124
• 全文大小：1343 K
• 卷排序：87

文摘

Perfusion computed tomography (PCT) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provide independent measurements of biomarkers related to tumor perfusion. The aim of this study was to compare the two techniques in assessing glioblastoma microvasculature.Materials and methodsTwenty-five patients diagnosed with glioblastoma (14 males and 11 females; 51 ± 11 years old, ranging from 33 to 70 years) were includede in this prospective study. All patients underwent both PCT and DCE-MRI. Imaging was performed on a 256-slice CT scanner and a 3-T MRI system. PCT yielded permeability surface-area product (PS) using deconvolution physiological models; meanwhile, DCE-MRI determined volume transfer constant (Ktrans) using the Tofts-Kermode compartment model. All cases were submitted to surgical intervention, and CD105-microvascular density (CD105-MVD) was measured in each glioblastoma specimen. Then, Spearman’s correlation coefficients and Bland-Altman plots were obtained for PS, Ktrans and CD105-MVD. P < 0.05 was considered statistically significant.ResultsTumor PS and Ktrans values were correlated with CD105-MVD (r = 0.644, P < 0.001; r = 0.683, P < 0.001). In addition, PS was correlated with Ktrans in glioblastoma (r = 0.931, P < 0.001). Finally, Bland-Altman plots showed no significant differences between PS and Ktrans (P = 0.063).ConclusionPCT and DCE-MRI measurements of glioblastoma perfusion biomarkers have similar results, suggesting that both techniques may have comparable utility. Therefore, PCT may serve as an alternative modality to DCE-MRI for the in vivo evaluation of glioblastoma microvasculature.