Use of New Techniques in Addition to IHC Applied to the Diagnosis of Melanocytic Lesions, With Emphasis on CGH, FISH, and Mass Spectrometry

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• 作者：P. Nagarajan ; M.T. Tetzlaff ; J.L. Curry ; V.G. Prieto ; ^{Vprieto@mdanderson.org}
• 关键词：Melanoma ; Diagnosis ; Immunohistochemistry ; Comparative genomic hybridization ; Fluorescence in situ hybridization ; Mass spectrometry
• 刊名：Actas Dermo-Sifiliográficas
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：108
• 期：1
• 页码：17-30
• 全文大小：7067 K
• 卷排序：108

文摘

Melanoma remains one of the most aggressive forms of cutaneous malignancies. While its diagnosis based on histologic parameters is usually straight forward in most cases, distinguishing a melanoma from a melanocytic nevus can be challenging in some instances, especially when there are overlapping clinical and histopathologic features. Occasionally, melanomas can histologically mimic other tumors and even demonstration of melanocytic origin can be challenging. Thus, several ancillary tests may be employed to arrive at the correct diagnosis. The objective of this review is to summarize these tests, including the well-established and commonly used ones such as immunohistochemistry, with specific emphasis on emerging techniques such as comparative genomic hybridization, fluorescence in situ hybridization and imaging mass spectrometry.