Evaluating the safety of forsythin from Forsythia suspensa leaves by acute and sub-chronic oral administration in rodent models

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• 作者：Zhong Han¹ ; ² ; ³ ; Xia-Ling Lei² ; ³ ; Hong Zhang² ; ³ ; Lu Liu² ; ³ ; Zhi-Sen Chen² ; ³ ; Wei Yang² ; ³ ; ^{yangwei0719@163.com} ; Zhao-Rong Lun¹ ;
• 关键词：Forsythin ; Acute toxicity ; Sub-chronic toxicity ; Safety
• 刊名：Asian Pacific Journal of Tropical Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：10
• 期：1
• 页码：47-51
• 全文大小：1001 K
• 卷排序：10

文摘

To access the toxicity of forsythin from Forsythia suspensa leaves and evaluate its safety.MethodsAcute toxicity was determined by oral administration of a single dose of 18 100 mg/kg forsythin in NIH mice. Sub-chronic toxicity was evaluated by oral administration of several doses of forsythin for 30 days at does of 0, 540, 1 620, and 6 480 mg/kg in SD rats.ResultsIn the acute toxicity study, mortality was not observed after 14 days. In addition, clinically relevant adverse effects, or variations in body weight or food consumption were not observed. Similarly, after 30 days in the sub-chronic toxicity study, no mortality or significant toxicological effects such as decreased food consumption, body weight, biochemical parameters and vital organs etc. were noticed.ConclusionThe results revealed that the forsythin from Forsythia suspensa leaves has low or no toxicity via oral administration, and therefore is suitable for further development and applications.