Correlation of RUNX3 expression with microvessel density in colorectal adenocarcinoma tissues and clinical significance

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• 作者：Jun Xue ; ^{yfyxuejun@163.com} ; Xue-Liang Wu ; Xian-Tao Huang ; Ming Qu ; Fei Guo ; Guang-Yuan Sun ; Peng-Cheng Zhang ; Lei Han ; Li-Ming Pan
• 关键词：Colorectal neoplasms ; RUNX3 ; Microvessel density ; Clinical significance
• 刊名：Asian Pacific Journal of Tropical Medicine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：10
• 期：1
• 页码：98-101
• 全文大小：457 K
• 卷排序：10

文摘

To study the expression of RUNX3 in colorectal adenocarcinoma tissues and its correlation with microvessel density (MVD), and investigate the clinical pathological prognostic significance of RUNX3 and MVD in patients with colorectal cancer.MethodsThe expression value of RUNX3 and MVD in 70 specimens’ colorectal adenocarcinoma tissues were detected by immunohistochemistry staining technique. The correlation between their expression and the clinicopathologic features was also investigated.ResultsThe expression value of RUNX3 and the positive rates of RUNX3 in colorectal adenocarcinoma tissues were 3.25 ± 1.14 and 25.71% (18/70). The expression value of MVD in colorectal adenocarcinoma tissues was 13.14 ± 3.23. Expression of RUNX3 and MVD value were correlated with CEA, serosal invasion, liver metastasis, lymph node metastasis, and TNM stage (P < 0.01). The expression value of RUNX3 had negative correlations with that of MVD.ConclusionsThe high expression of RUNX3 could inhibit tumor microvascular generation in order to have negative control response on invasion and distant metastasis.