Continuing rise in oropharyngeal cancer in a high HPV prevalence area: A Danish population-based study from 2011 to 2014

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• 作者：Amanda-Louise Fenger Carlander^a ; Christian Grø ; nhø ; j Larsen^a ; David Hebbelstrup Jensen^a ; Emilie Garnæ ; s^a ; Katalin Kiss^b ; Luise Andersen^b ; Caroline Holkmann Olsen^c ; Maria Franzmann^d ; Estrid Hø ; gdall^e ; Susanne K. Kjæ ; r^f ; ^k ; Bodil Norrild^g ; Lena Specht^h ; Elo Andersenⁱ ; Thomas van Overeem Hansen^j ; Finn Cilius Nielsen^j ; Christian von Buchwald^a ; ^{Christian.von.buchwald@regionh.dk}
• 关键词：HPV ; Oropharynx ; Base of tongue ; Tonsillar ; Incidence ; p16 ; Genotype ; HPV16
• 刊名：European Journal of Cancer
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：70
• 期：Complete
• 页码：75-82
• 全文大小：849 K
• 卷排序：70

文摘

The incidence of oropharyngeal squamous cell carcinoma (OPSCC) continues to rise in Eastern Denmark. A total of 62% of all OPSCC cases included were human papillomavirus-positive (HPV+), showing a high HPV prevalence. HPV16 was the predominant type (86%), followed by HPV33 (6%), and HPV35 (4%). Additional HPV-types were also identified, including HPV18, 45, 56 and 67. The burden of HPV+ OPSCC in Eastern Denmark is expected to surpass that of cervical cancer in 2016.