Application of mesoscale simulation to explore the aggregate morphology of pH-sensitive nanoparticles used as the oral drug delivery carriers under different conditions

详细信息    查看全文

• 作者：Yan Wang^a ; ^b ; Bo Zhi Chen^b ; Yue Jin Liu^a ; Zhi Min Wu^a ; ^{xdwuzm@xtu.edu.cn} ; Xin Dong Guo^b ; ^{xdguo@buct.edu.cn}
• 关键词：pH-sensitive nanoparticles ; Oral drug delivery ; Dissipative particle dynamics
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：151
• 期：Complete
• 页码：280-286
• 全文大小：3249 K
• 卷排序：151

文摘

The effects on formation of PLGA/HP55 nanoparticles were explored by DPD simulation. The optimal ratio of PLGA and HP55 ranges from 1:1 to 2:1. Different morphologies of nanoparticles would affect the loading of insulin. Ionized HP55creates favorable condition for release of insulin at pH > 5.5.