Sequential delivery of chlorhexidine acetate and bFGF from PLGA-glycol chitosan core-shell microspheres

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• 作者：Ming-Mao Chen^a ; Huan Cao^a ; Yuan-Yuan Liu^a ; Yan Liu^b ; Fei-Fei Song^a ; Jing-Di Chen^a ; Qi-Qing Zhang^a ; ^c ; ^{zhangqiq@126.com} ; Wen-Zhi Yang^d ; ^{wenzhi_yang@sina.com}
• 关键词：Core-shell microspheres ; Controlled release ; PLGA ; Glycol chitosan ; Growth factor ; Chlorhexidine acetate
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：151
• 期：Complete
• 页码：189-195
• 全文大小：2308 K
• 卷排序：151

文摘

PLGA-GC core-shell microspheres were fabricated for delivering two model drugs in sequence. The CHA loaded in the shell was rapidly released, and the proteins at the core exhibited a sustained release. The released CHA and bFGF retained their antimicrobial activity and bioactivity. The microspheres exhibited non-cytotoxicity and had a good biocompatibility. This sequential delivery system has the potential for preventing infection and promoting wound healing.