Self dispersing mixed micelles forming systems for enhanced dissolution and intestinal permeability of hydrochlorothiazide

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• 作者：Amal A. Sultan ^{amal_aahmed2009@yahoo.com} ; Sanaa A. El-Gizawy ^{selgizawy@hotmail.com} ; Mohamed A. Osman ^{mosman4444@yahoo.com} ; Gamal M. El Maghraby ; ^{gmmelmag@yahoo.com}
• 关键词：Hydrochlorothiazide ; Mixed micelles ; Colloidal particles ; Nanostructures ; Rapid dissolution
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：149
• 期：Complete
• 页码：206-216
• 全文大小：1894 K
• 卷排序：149

文摘

Solid self dispersing mixed micelles forming systems (MMFS) were prepared. Self dispersing MMFS enhanced the dissolution rate of hydrochlorothiazide. The presence of hydrophilic polymers in MMFS was beneficial. Poloxamer incorporating MMFS enhanced hydrochlorothiazide intestinal absorption.