Graphene quantum dots with nitrogen-doped content dependence for highly efficient dual-modality photodynamic antimicrobial therapy and bioimaging

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• 作者：Wen-Shuo Kuo^a ; ^b ; ^c ; ¹ ; ^{wenshuokuo@mail.ncku.edu.tw} ; Hua-Han Chen^d ; ¹ ; Shih-Yao Chen^e ; ¹ ; Chia-Yuan Chang^c ; Pei-Chi Chen^b ; ^f ; Yung-I Hou^b ; Yu-Ting Shao^b ; ^g ; Hui-Fang Kao^b ; ^h ; Chih-Li Lilian Hsu^f ; ^g ; Yi-Chun Chenⁱ ; Shean-Jen Chen^a ; ^c ; Shang-Rung Wu^f ; ^j ; ^{z10208056@email.ncku.edu.tw} ; Jiu-Yao Wang^b ; ^f ; ^g ; ^{a122@mail.ncku.edu.tw}
• 关键词：Reactive oxygen species ; Photodynamic therapy ; Nitrogen-doped graphene quantum dot ; Antimicrobial ; Photostability ; Contrast probe
• 刊名：Biomaterials
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：120
• 期：Complete
• 页码：185-194
• 全文大小：1486 K
• 卷排序：120

文摘

Reactive oxygen species is the main contributor to photodynamic therapy. The results of this study show that a nitrogen-doped graphene quantum dot, serving as a photosensitizer, was capable of generating a higher amount of reactive oxygen species than a nitrogen-free graphene quantum dot in photodynamic therapy when photoexcited for only 3 min of 670 nm laser exposure (0.1 W cm-2), indicating highly improved antimicrobial effects. In addition, we found that higher nitrogen-bonding compositions of graphene quantum dots more efficiently performed photodynamic therapy actions than did the lower compositions that underwent identical treatments. Furthermore, the intrinsically emitted luminescence from nitrogen-doped graphene quantum dots and high photostability simultaneously enabled it to act as a promising contrast probe for tracking and localizing bacteria in biomedical imaging. Thus, the dual modality of nitrogen-doped graphene quantum dots presents possibilities for future clinical applications, and in particular multidrug resistant bacteria.