Engineered gadolinium-doped carbon dots for magnetic resonance imaging-guided radiotherapy of tumors

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• 作者：Fengyi Du^a ; ¹ ; Lirong Zhang^b ; ¹ ; Li Zhang^c ; ¹ ; Miaomiao Zhang^a ; ¹ ; Aihua Gong^a ; Youwen Tan^a ; Jiawen Miao^a ; Yuhua Gong^a ; Mingzhong Sun^d ; Huixiang Ju^d ; ^{2659661466@qq.com} ; Chaoyang Wu^c ; ^{wuchaoyang9@163.com} ; Shenqiang Zou^a ; ^{1210xyz@163.com}
• 关键词：MRI ; Contrast agents ; Gadolinium ; Carbon dots ; Radiotherapy
• 刊名：Biomaterials
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：121
• 期：Complete
• 页码：109-120
• 全文大小：3584 K
• 卷排序：121

文摘

The effectiveness of radiotherapy can decrease due to inaccurate positioning of machinery and inherent radioresistance of tumors. To address this issue, we present a novel theranostic nanoplatform based on gadolinium-doped carbon dots (Gd-doped CDs) designed specifically for magnetic resonance imaging (MRI)-guided radiotherapy of tumors. The Gd-doped CDs (∼18 nm) with dispersibility in water and stable photoluminescence were synthesized via a one-step hydrothermal approach. After tail vein injection of the Gd-doped CDs, they exhibited a relatively long circulation time (∼6 h), enabled efficient passive tumor targeting. Gd-doped CDs accumulate in the kidney and could be cleared out of the body from bladder. Importantly, they exhibited favorable biocompatibility with excellent performance in longitudinal relaxivity rate (r1) of 6.45 mM−1S−1 and radiosensitization enhancements. These results show that Gd-doped CDs are excellent T1 contrast agents and radiosensitizers, possessing great promise for MRI-guided radiotherapy of tumors.