Thermo-responsive human α-elastin self-assembled nanoparticles for protein delivery

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• 作者：Jae Dong Kim¹ ; Youn Jae Jung¹ ; Chang Hee Woo ; Young Chan Choi ; Ji Suk Choi ; Yong Woo Cho ; ^{ywcho7@hanyang.ac.kr}
• 关键词：Human α-elastin ; Thermo-responsive ; Self-assembly ; Nanoparticles ; PEGylation ; Protein delivery system
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：149
• 期：Complete
• 页码：122-129
• 全文大小：2413 K
• 卷排序：149

文摘

We designed a thermo-responsive, self-assembled α-elastin nanoparticle (PhENP). PhENPs showed sol-to-particle transition above a critical temperature (32 °C). PhENPs are able to encapsulate amounts of insulin/BSA upon simple mixing. The release profiles of insulin and BSA show sustained release over 72 h. PhENPs provide a useful tool for a range of injectable protein delivery systems.