Enhancing osteogenic differentiation of MC3T3-E1 cells by immobilizing RGD onto liquid crystal substrate

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• 作者：Shaopeng Wu ; Xiaohui Yang ; Wenqiang Li ; Lin Du ; Rong Zeng ; Mei Tu ; ^{tumei@jnu.edu.cn}
• 关键词：Liquid crystal ; GRGDF modification ; Cell behavior ; Osteogenic differentiation
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：973-981
• 全文大小：1655 K
• 卷排序：71

文摘

A novel type of GRGDF-immobilized liquid crystalline matrices was fabricated and served as a substrate for the in vitro culture of MC3T3-E1 cells. The lower RGD density might provide a better condition for initial cell adhesion and proliferation, up-regulation of ALP expression levels, and mineralization. The intrinsic liquid crystalline feature of OPC matrix, instead of RGD efficiency, promoted initial cell adhesion. Properties of the liquid crystalline OPC matrix together with the stable receptor-ligand binging synergistically modulated MC3T3-E1 cell behavior.