Multifunctional theranostic Pluronic mixed micelles improve targeted photoactivity of Verteporfin in cancer cells

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• 作者：Diogo Silva Pellosi^a ; Italo Rodrigo Calori^b ; Leonardo Barcelos de Paula^a ; Noboru Hioka^b ; Fabiana Quaglia^c ; Antonio Claudio Tedesco^a ; ^{atedesco@usp.br}
• 关键词：Verteporfin ; Drug delivery ; Nanotechnology ; Phototherapy ; Cancer ; Targeting
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：1-9
• 全文大小：986 K
• 卷排序：71

文摘

We optimized the theranostic mixed micelles – verteporfin formulations. Multifunctional Pluronic micelles formed nano-sized spherical nanoparticles. Biotin surface conjugation allowed higher intracellular uptake in cancer cells. Rhodamine-B inclusion provided a powerful tool for imaging purposes. Functionalized nanoparticles showed marked phototoxicity after laser irradiation.