Self-fluorescent drug delivery vector based on genipin-crosslinked polyethylenimine conjugated globin nanoparticle

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• 作者：Yan Zhang ; Lina Mao ; Juan Liu ; Tianjun Liu ; ^{liutianjun@hotmail.com}
• 关键词：Self-fluorescence ; Globin ; Drug delivery ; Fluorescence imaging ; Genipin-crosslink
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：17-24
• 全文大小：1052 K
• 卷排序：71

文摘

Hemoglobin, an endogenous peptide pool, fabricated as the drug carrier with good biocompatibility was reported first time. The Genipin-crosslinked globin and PEI nanoparticles as drug delivery system had tumor cell line selectivity. Genipin-crosslinked globin and PEI nanoparticles had high photo-stable and enzymolysis-stable self-fluorescence. This self-fluorescence could be imaged both in vitro and in vivo.